21医学小白发表于：2010/12/23 21:58:00
回12L姑娘，听了姑娘的话觉得还是想捐……LZ体质还好（来MC时也不会很痛，这算是项指标么囧），所以应该打动员剂的时候不会有很大反应的吧……就算有也一定听姑娘的话不反悔，等寒假回家让母上大人好好给LZ补补
回14L姑娘，LZ被告知捐干细胞的时候是在省医院，应该不会出这种岔子的
22= =发表于：2010/12/23 22:00:00
23= =发表于：2010/12/23 22:01:00
24= =发表于：2010/12/23 22:01:00
我只能说LZ运气好啊
这是缘分
我是干细胞志愿者 = =+三年了
上个月刚被询问是否要继续加入 回答了是
救人一命胜造七级浮屠
能救人还是救吧
但是也是要看LZ当时的身体状况如何
如果换做是我的 我肯定会捐的 毕竟人活着不容易啊
25医学小白发表于：2010/12/23 22:03:00
LS几层姑娘说得有点吓人…………
LZ真的很怕疼也怕自己会残掉TVT
可是如果不同意的话总觉得如果LZ本来捐了就能治好人家了的话那LZ不就太自私了么
26= =发表于：2010/12/23 22:08:00
27= =发表于：2010/12/23 22:09:00
现在在血液科，想说，希望LZ考虑清楚，如果决定捐了，一定请坚持到底
会找陌生人移植的病人，基本都是自己亲人配不上没办法移植的
移植是很多人最后且唯一的治疗方法
28医学小白发表于：2010/12/23 22:12:00
看不到LS姑娘说的啥
fs
fs
fs
29= =发表于：2010/12/23 22:12:00
The risks of a complication depend on patient characteristics, health care providers and the apheresis procedure, and the colony-stimulating factor used (G-CSF, GM-CSF). G-CSF drugs include Filgrastim (Neupogen, Neulasta), and lenograstim (Graslopin).
Filgrastim is typically dosed in the 10 microgram/kg level for 4–5 days during the harvesting of stem cells. The documented adverse effects of filgrastim include splenic rupture (indicated by left upper abdominal or shoulder pain, risk 1 in 40000), Adult respiratory distress syndrome (ARDS), alveolar hemorrage, and allergic reactions (usually expressed in first 30 minutes, risk 1 in 300).[30][31][32] In addition, platelet and hemoglobin levels dip post-procedure, not returning to normal until one month.[32]
The question of whether patients over 65 react the same as patients under 65 has not been sufficiently examined. Coagulation issues and inflammation of atherosclerotic plaques are known to occur as a result of G-CSF injection.[31] G-CSF has also been described to induce genetic changes in mononuclear cells of normal donors.[31] There is evidence that myelodysplasia (MDS) or acute myeloid leukaemia (AML)can be induced by GCSF in susceptible individuals.[33]
Blood was drawn peripherally in a majority of patients, but a central line to jugular/subclavian/femoral veins may be used in 16% of women and 4% of men. Adverse reactions during apheresis were experienced in 20% of women and 8% of men, these adverse events primarily consisted of numbness/tingling, multiple line attempts, and nausea.[32]
A study involving 2408 donors (18–60 years) indicated that bone pain (primarily back and hips) as a result of filgrastim treatment is observed in 80% of donors by day 4 post-injection.[32] This pain responded to acetaminophen or ibuprofen in 65% of donors and was characterized as mild to moderate in 80% of donors and severe in 10%.[32] Bone pain receded post-donation to 26% of patients 2 days post-donation, 6% of patients one week post-donation, and <2% 1 year post-donation.It is recommended for people with back pain history, not to be a donor.[32] Other symptoms observed in more than 40% of donors include myalgia, headache, fatigue, and insomnia.[32] These symptoms all returned to baseline 1 month post-donation, except for some cases of persistent fatigue in 3% of donors.[32] . In one metastudy that incorporated data from 377 donors, 44% of patients reported having adverse side effects after peripheral blood HSCT.[33] Side effects included pain prior to the collection procedure as a result of GCSF injections, post-procedural generalized skeletal pain, fatigue and reduced energy.[33]
A study that surveyed 2408 donors found that serious adverse events (requiring prolonged hospitalization) occurred in 15 donors (at a rate of 0.6%), although none of these events were fatal.[32] Donors were not observed to have higher than normal rates of cancer with up to 4–8 years of follow up.[32] One study based on a survey of medical teams covered approximately 24,000 peripheral blood HSCT cases between 1993 and 2005, and found a serious cardiovascular adverse reaction rate of about 1 in 1500.[31] This study reported a cardiovascular-related fatality risk within the first 30 days HSCT of about 2 in 10000. For this same group, severe cardiovascular events were observed with a rate of about 1 in 1500. The most common severe adverse reactions were pulmonary edema/deep vein thrombosis, splenic rupture, and myocardial infarction. Haematological malignancy induction was comparable to that observed in the general population with only 15 reported cases within 4 years.[31]
30医学小白发表于：2010/12/23 22:15:00
谢谢LS姑娘，LZ刚刚考完六级看到英文真是内牛满面
转身拿字典去
31= =发表于：2010/12/23 22:27:00
32= =发表于：2010/12/23 22:31:00
33= =发表于：2010/12/23 22:35:00
现在在血液科，想说，希望LZ考虑清楚，如果决定捐了，一定请坚持到底
会找陌生人移植的病人，基本都是自己亲人配不上没办法移植的
移植是很多人最后且唯一的治疗方法
======
lz好好考虑下吧，要找到匹配的捐献者很难得的
很多事情都对身体有影响，包括你每天都做的一些习惯，包括你偶尔做的献血，也能查到许多对身体有害的文章，但是能救人一命的话，有些事是值得的，知道自己说这话圣母了，但是事关人命，也许你这是被捐献者全家最后唯一的希望了
34= =发表于：2010/12/23 22:37:00
你们有没有见过直播捐献骨髓的
好恐怖啊
就见拿着摇个不停
35医学小白发表于：2010/12/23 22:39:00
谢谢31L姑娘，LZ觉得29L姑娘也应该是好心要帮LZ的，姑娘莫激动，汗
LZ用不给力的英文加翻译机大概看懂了29L的主要意思，就是捐献有可能会引起各种各样LZ还是不懂的病，但是几率比较小而且不是致命的……结合LS姑娘们的建议就是：捐献干细胞是一件有风险的事，不同体质的人影响是不同的，应该在充分了解以及和家人达成一致的情况下去捐献。
谢谢所有给LZ意见的姑娘们，LZ决定这两天多查查资料让父母问问懂的医生朋友，如果没很大的问题就同意好了
36= =发表于：2010/12/23 22:40:00
37= =发表于：2010/12/23 22:40:00
成年人捐干细胞不从骨髓里抽还能从哪里抽啊
反正不是个舒服的过程，但是我也觉得LZ能有机会帮到别人真是挺缘分的。。。
38= =发表于：2010/12/23 22:41:00
39= =发表于：2010/12/23 22:42:00
40= =发表于：2010/12/23 22:47:00
谢谢31L姑娘，LZ觉得29L姑娘也应该是好心要帮LZ的，姑娘莫激动，汗
LZ 用不给力的英文加翻译机大概看懂了29L的主要意思，就是捐献有可能会引起各种各样LZ还是不懂的病，但是几率比较小而且不是致命的……结合LS姑娘们的 建议就是：捐献干细胞是一件有风险的事，不同体质的人影响是不同的，应该在充分了解以及和家人达成一致的情况下去捐献。
谢谢所有给LZ意见的姑娘们，LZ决定这两天多查查资料让父母问问懂的医生朋友，如果没很大的问题就同意好了
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谢谢lz的理解。29L和38L都是我。我只是本着说话负责的态度，既然要说捐了没问题，一定是要有根据说的。虽然wiki未必100%正确，但是至少人家有明确的引用文献，扎扎实实的案例研究和分析，而且正文里面写得明明白白是外周造血细胞捐献的案例研究，并且都是在讨论使用动员剂的副作用。对于31L那种看也没看就妄下论断的鸡血型做法表示无奈。